International Journal

Co2 emission, power consumption and economic growth in Bangladesh: an ARDL bound testing approach

2017-01-01T00:00:00Z

Co2 emission, power consumption and economic growth in Bangladesh: an ARDL bound testing approach Wahid, A.N.M.; Hossain, Anwar; Mahmud, Kazi Tanvir; Alom, Khairul This paper focuses on the empirical relationship between economic growth, co2 emission, power consumption, fossil fuel energy consumption and financial development of Bangladesh using data of 1985-2013. Findings indicate that a significant relationship exists between economic growth and power consumption, economic growth and fossil fuel energy consumption in the long run. The long run relationship between co2 emission and economic growth as well as financial development is insignificant. Whereas, Granger causality shows that bidirectional association exists among economic growth and power consumption, financial development and economic growth, fossil fuel energy consumption and economic growth in the short run. However, unidirectional casualty has been found among power consumption to financial development, co2 emission to power consumption, fossil fuel energy consumption to financial development, co2 emission to financial development and co2 emission to fossil fuel energy consumption. Error correction mechanism confirms that except power consumption all the explanatory variables quick return to equilibrium in the short run.

Self-microemulsifying: a new approach of lipid based drug delivery systems

2017-01-01T00:00:00Z

Self-microemulsifying: a new approach of lipid based drug delivery systems Hasan, Md. Mehdi; Rahman, Md. Mizanur; Hasan, Mahbub; Islam, S.M. Nazrul; Hasan, Masum Al; Rashid, Harun Ar Solubility is one of the key factor in drug formulation in order to ensure better bioavailability. As 40% of new drugs are poorly soluble, it has become a matter of concern and challenge for the formulation scientists with regard to solubility and bioavailability. Though formulation approaches like solid dispersions, complexation, pH modification exist, but there are areas of further research and development for better approaches. Lipid-based drug delivery systems (LBDDS) are one of the emerging technologies designed to address such challenges in recent time. These systems have shown great promise which can lead to increased solubilization and absorption, resulting in enhanced bioavailability. This review provides a comprehensive understandings of Lipid-based drug delivery systems especially for oral delivery, from both physicochemical and biopharmaceutical perspectives. This review also focuses on advanced techniques and processes, along with a brief discussion of various lipid excipients and their characterization.

A key approach on dissolution of pharmaceutical dosage forms

2017-01-01T00:00:00Z

A key approach on dissolution of pharmaceutical dosage forms Hasan, Md. Mehdi; Rahman, Md. Mizanur; Islam, Md Rakibul; Hasan, Hasanuzzaman; Hasan, Md Mehedi; Rashid, Harun Ar Dissolution testing is a critical methodology which is widely utilized in the development of a new pharmaceutical product. The test, in its simplest form, consists of placing the formulation in a dissolution apparatus containing suitable dissolution medium, allowing it to dissolve over a specified period of time and then assaying the resultant solution using appropriate analytical method to determine the amount of drug. Dissolution tests are relevant for an array of investigations like drug degradation profiles, stability and shelf life studies, physical and mechanical testing of dosage forms, incoming QC testing on raw materials etc. The present review outlines the recent findings on various dissolution apparatuses, their modifications, methods for degassing of media like Helium sparging, Heating and filtering, Vacuum degassing, sonication and dissolution testing of various dosage forms like Immediate Release (IR) Dosage forms, Delayed Release Dosage Forms, Extended Release Dosage Forms, Transdermal Delivery Systems, Powders, Chewable Tablets, Buccal Tablets, Chewing Gums, Soft Gelatin Capsule, Aerosols, Suppositories and other Semisolids. This article presents, a short review on guidelines for dissolution profile testing, particularly focusing on the recommendations regarding statistical methods for assessing profile similarly. In this context, the guidelines on in vitro/in vivo correlations and on granting bio waivers are outlined briefly. The goal of this article is to give a survey of the current guidelines, including a description and discussion of the recommended methods for data analysis

Development and validation of method for determination of esomeprazole and naproxen from cobination product by hplc

2015-01-01T00:00:00Z

Development and validation of method for determination of esomeprazole and naproxen from cobination product by hplc Bhuyian, Md. Habib Ullah; Tareque, Md. Isha; Islam, A.F.M Ariful; Rashid, Md. Harun Ar A simple selective and rapid reversed phase high performance liquid chromatographic (RPHPLC) method for the analysis Esomeprazole and Naproxen has been developed and validated. The separation was achieved from HPLC Column (Cogent, C18 250mm x 4.6 mm, 5 µm) with a mobile phase consisting (Buffer: Acetonitrile: Methanol = 50:40:10, add 0.1% v/v Triethylamine in above mixture and finally adjust with glacial acetic acid to a pH 7.0) flow rate 1.0 ml/min with UV detection at 303 nm. The method was specific and it was observed that no interference with diluents. Proposed method is accurate with (99.87%-100.08%) recovery for Naproxen and (99.44%-99.87%) recovery for Esomeprazole. The proposed method was accurate, and precise for the quantification of Esomeprazole and Naproxen in the tablet. The proposed method can also be used for routine analysis in quality control. The method was validated for the parameters like selectivity, sensitivity, precision, intermediate precision, accuracy, linearity, recovery & stability . This RP -HPLC method is suitable for determining the concentration of Esomeprazole and Naproxen in tablet and it can applied for routine analysis for determination of the Esomeprazole and Naproxen from dosage form.

Screening of antidiarrhoeal activity of three reputed medicinal plants of Bangladesh

2015-01-01T00:00:00Z

Screening of antidiarrhoeal activity of three reputed medicinal plants of Bangladesh Hossain, Mohammad Taleb; Mamun, Abdullah Al; Asadujjaman, Md.; Rahman, Md. Habibur; Morshid, Gazi Monjur Anonna squamosa Linn. (Fam: Anonnaceae), Calotropis procera R. Br. (Fam: Asclepiadaceae), and Piper betel Linn. (Fam: Piperaceae) leaves have been used in conventional therapies for various disease conditions, including diarrhea. So, the present study was aimed to evaluate the antidiarrhoeal activity of ethanol extracts of the leaves of the above mentioned plants. Antidiarrhoeal activity was evaluated against an experimental model of castor oil-induced diarrhea in mice. In antidiarrheal activity test, oral administration of the mentioned ethanol extracts (250 and 500 mg/kg) showed significant (P<0.01) and dose-dependent inhibition. Onset of diarrhea after administration of 250 mg/kg and 500 mg/kg of A. squamosa were 88.8 mins and 102.6 mins, of C. procera were 83.4 mins and 118.2 mins, and of P. betelwere 81.0 mins and 115.8 mins, respectively as compared to 70.2 mins and 131.4 minsdemonstrated by control (1% Tween-80 in saline) and positive control (Loperamide), respectively. The result indicates the presence of some active principles in the plant extracts which might have a correlation with the revealed anti-diarrhoeal activities of these plants. The results also justify their traditional uses in the treatment of diarrhea

Compensatory strategy on ocular drug delivery system

2017-01-01T00:00:00Z

Compensatory strategy on ocular drug delivery system Hasan, Md. Mehdi; Moniruzzaman, Md.; Anee, Mubashwera; Rahaman, Md.Saydur; Rabbani, Golam; Banik, Kallol; Rashid, Harun Ar Ocular anatomy and physiology is very unique which is why it creates a challenge in developing drugs given by ocular routes. The Eye has several layers of tissues in it. This route is extremely effective due to its rapid onset of action and small dose requirement. Transcorneal penetration is the route of absorption ofdrug.Several different dosage forms are being developed e.g nanoparticles, liposomes, nanomicelles and microemulsion to overcome difficul ties in drug delivery by this route. This review focused on ocular drug delivery has become the standard in modern pharmaceutical design and several possible routes of drug delivery into the ocular tissues

Mixture design experiment on dissolution of pioglitazone hcl solid dispersion as affected by hydrophilic polymers interaction

2016-01-01T00:00:00Z

Mixture design experiment on dissolution of pioglitazone hcl solid dispersion as affected by hydrophilic polymers interaction Rashid, Harun Ar; Faisal, Khandokar Sadique; Bhyian, Md. Habib Ullah; Alam, Md. Jahangir; Hasan, Md.Mehdi Methods available to improve dissolution include salt formation, micronization and addition of solvent or surface active agents. The development of solid dispersions as a practically viable method to enhance bioavailability of poorly water soluble drugs overcame the limitations of those previous approaches. No studies, to date, have systematically examined the effect of different hydrophilic polymer on the dissolution of poorly water soluble drug. In this study, interaction effect of propyl methyl cellulose cp15 (HPMC cp15), polyethylene glycol 6000 (PEG 6000), povidone 30 (PVP K30), eudragit EPO, polaxamer 407 on dissolution of pioglitazone HCl solid dispersion were investigated by a mixture design experiment. Blends of HPMC, PEG 6000, PVP K30, eudragit and polaxamer 407 were prepared according to an augmented simplex-centroid mixture design (10 points) and the drug polymer ratio was 1:3 in the solid dispersion formulation. An appropriate mathematical model was fitted to express the response. The synergistic effect of HPMC : PG : POLOXMER, had shown to be much stronger in quaternary blends. In addition, Eudragit showed an tagonistic effect (p<.05). The contour plot reveled the effects of the tertiary bends on the dissolution of pioglitazone. Tertiary blend of HPMC, PVP and PEG demonstrated a synergistic effect on the dissolution, at higher proportion of PEG. This study suggested that a mixture design approach could serve as a valuable tool in better elucidating and predicting the interaction effects beyond the conventional polymers blends.

Pharmaceutical pre formulation for product development and analytical techniques use in new dosage form

2017-01-01T00:00:00Z

Pharmaceutical pre formulation for product development and analytical techniques use in new dosage form Hasan, Md. Mehdi; Habib, Sabbir Al; Islam, Mumu Mishouri; Islam, Md. Mohshin; Karim, Md. Salimul; Banik, kallol; Rashid, Harun Ar Fundamentals to preformulation studies are analytical techniques. Evaluation of the quality of materials, precursors of products or final product is not possible without them. Measuring pharmacological and biological response in the clinical and preclinical stages are also not possible without them. Analytical techniques should be selected based on several categories such as specificity, accuracy, precision, sensitivity, and speed of a test must be verified for selection of the method. Several analytical techniques like Spectroscopic, Chromatographic, Thermal methods and some specific detection methods like Capillary electrophoresis are very convenient method for generating preformulation data. The intrinsic chemical data and physical properties of every drug are distinctively considered before development of pharmaceutical formulation. This property of drug act as the basic structure that is responsible for the binding of drug with other pharmaceutical ingredients. Several research scientist carries out these preformulation studies and they are again reviewed later. When a preformulation study is executed on a newly synthesized compounds or extracted compound, several crucial information such as the degradation process, any adverse conditions relevant to the drug, bioavailability, pharmacokinetics and formulation of similar compound and toxicity can be obtained. Preformulation studies strengthen the scientific foundation of the steerage, give restrictive relief and conserve resources within the drug development and analysis method, improve public safety standards, enhance product quality within the fabrication of indefinite quantity type. Objective of preformulation study is to develop the exquisite, stable, effective and safe indefinite quantity kind by establishing kinetic rate profile, compatibility with the opposite ingredients and establish physicochemical parameter of new drug substances. Polymorphic substances who have both amorphous and crystal forms shows totally different chemical, physical and therapeutic description of the drug molecule. The main purpose of this review article focuses on the various preformulation factors which distinctly impacts the development of new dosage form like drug solubility, partition coefficient, dissolution rate, polymorphic forms and stability. The present article is framed with the target to produce an in-depth insight the appliance of Analytical Techniques in Preformulation Study

Comparative study of anti-hyperlipidemic effect of zingiber officinale,momordica charantia, trigonella foenum-graecum, dillenia indica and tamarindus indica.

2015-01-01T00:00:00Z

Comparative study of anti-hyperlipidemic effect of zingiber officinale,momordica charantia, trigonella foenum-graecum, dillenia indica and tamarindus indica. Chowdhury, Asif Alam; Sukul, Abhijit; khan, Imdadul huque; Mamun, Yasir; Chowdhury, Imran; Raihan, Sheikh Zahir This dissertation aimed to compare the antihyperlipidemic effects of methanolic extract of Zingiber officinale, Momordica charantia, Trigonella foenum-graecum, Dillenia indica and Tamarindus indica in hyperlipidemic animal models. Atorvastatin was used as standard drug. The crude extract (100 mg/kg) of these significantly prevented the increase in low density lipoprotein (LDL), total cholesterol (TC), triglyceride (TG) and significantly increased the HDL level in blood serum. The reduction in serum level of above parameters was compared with atorvastatin and then within themselves. Among the five samples, Zingiber officinale extract showed significant Cholesterol reduction property (p<0.001) compared to other extracts. Momordica charantia & Dilenia indica (p<0.001) significantly increased the blood HDL cholesterol level. Zingiber officinale, Dilenia indica & Tamarindus indica significantly reduced LDL level in blood (p<0.001). Momordica charantia & Trigonella foenum-graecum significantly reduced TG level (p<0.001) in blood serum of rats. So, the above results confirmed that all extracts are potent against hyperlipidemia

Granulation techniques & its updated modules

2016-01-01T00:00:00Z

Granulation techniques & its updated modules Jannat, Esratun; Arif, Abdullah Al; Hasan, Md. Mehdi; Zarziz, Abdullah Bin; Rashid, Harun Ar Granulation is the process in which primary powder particles are made to adhere to form larger multiparticle entities called granules. Granulation is required to avoid segregation, enhance the flow of powder, to produce uniform mixture, to produce dust free formulation, to eliminate poor content uniformity and to improve compaction characteristics of mix. Granulation method is mainly divided into two types: wet granulation and dry granulation. Like any other scientific field, pharmaceutical granulation technology also continues to change, and arrival of novel and innovative technologies are inevitable. This review focuses on the recent progress in the granulation techniques and technologies such as pneumatic dry granulation, reverse wet granulation, steam granulation, moisture-activated dry granulation, thermal adhesion granulation, freeze granulation, and foamed binder or foam granulation. This review gives an overview ofthese with a short descriptionabout each development along with its significance and limitations. During the formulation development, each drug substance poses a unique challenge that must be taken into consideration at the process selection stage by the formulation development scientists.