Contemporary investigation on nasal spray drug delivery system

Abstract

Nasal route has been a preferred choice of administrating certain types of drugs. It has been explored as an alternative route for administration of vaccines and biomolecules such as proteins, peptides and non -peptide drugs, hence it has attracted the interest of scientific community. Nasal route is beneficial for the drugs which are unstable on ora l administration because they are significantly degraded in GIT or metabolized by first pass effect in liver. Nasal route is alternative to parenteral therapy and also useful for long term therapy. Nasal mucosa is highly vascularized and most permeable giv ing rapid absorption and onset of action. Nasal route is noninvasive, widely used for the local treatment may also be used for systemic therapy as drug directly goes in systemic circulation. Nasal route gives good absorption of small molecules, then that o f large molecules can be increased by absorption promoters. Thus, Intranasal therapy holds a great promise of research to understand the potentiality and limitation of it and possible use of this route for delivering different drugs. The aim of this review is to discuss the prospect of nasal spray as an innovative drug delivery system for local or systemic drug administration. It is expected that this review will help to understand and further to develop suitable intra - nasal formulations to achieve specific therapeutic objectives