Self-microemulsifying: a new approach of lipid based drug delivery systems

Abstract

Solubility is one of the key factor in drug formulation in order to ensure better bioavailability. As 40% of new drugs are poorly soluble, it has become a matter of concern and challenge for the formulation scientists with regard to solubility and bioavailability. Though formulation approaches like solid dispersions, complexation, pH modification exist, but there are areas of further research and development for better approaches. Lipid-based drug delivery systems (LBDDS) are one of the emerging technologies designed to address such challenges in recent time. These systems have shown great promise which can lead to increased solubilization and absorption, resulting in enhanced bioavailability. This review provides a comprehensive understandings of Lipid-based drug delivery systems especially for oral delivery, from both physicochemical and biopharmaceutical perspectives. This review also focuses on advanced techniques and processes, along with a brief discussion of various lipid excipients and their characterization.