Absorption and drug development: solubility, permeability, and charge state

Abstract

Of the hundreds of thousands of compounds synthesized each year, most have almost no chance of becoming drugs. This problem exists because most molecules lack eht drug-like poperties necessary to enable them to be effective in vivo. To address this issue, Alex Avdeef’s Absorption and Drug Development shows the reader how to examine a compound’s pharmaceutical properties, emphasizing oral absorption. This book explains the different physiochemical methods currently used to analyze drug candidates and how to interpret these methods.