Mild condition synthesis and biological activity: 1, 2, 3, 4 - tetrahydro - 6 - hydrobenz[a]anthracene - 1, 7, 12 - trione

Abstract

The synthesis of new compounds with abroad spectrum of activity is caused by a large number of existing drugs with significant side effects, which is needed to minimize. The angucycline group is not only visual art but also have their own chemical properties like pharmaceutical. This group is the largest group and engineered natural products, rich in biological activities and chemical scaffolds. Mild condition, synthesis of 6-hydroxy-1, 2, 3, 4-tetrahydrobenz[a]anthracene 6 through Krohn's method and simple aerial oxidation of this compounds 6 synthesized 1, 2, 3, 4 - Tetrahydro-6-HydroxyBenz[a] anthracene-1, 7, 12 –Trione 7, a basic skeleton of angucycline and tested antimicrobial activity, and found moderately biological active towards Bacillussubtilis, Streptococcus-β-haemolitycus and Escherichia coli. Quantum-mechanical calculations for compounds-substrates by means of computer modeling were carried out. The high degree of affinity to the chosen biological target gives us a promising opportunity in displaying antitumor activity of that compounds. By in silica studies the possibility of displaying biological activity of synthesized compounds was predicted.