Molecular biopharmaceutics: aspects of drug characterisation, drug delivery and dosage form evaluation

Abstract

Molecular Biopharmaceutics concerns physicochemical characterization, membrane transport and bioavailability of mainly small (pro)drug substances/ candidates. The book describes experimental and predictive methods, ie from chemical stability, dissolution, passive diffusional and carrier-mediated membrane permeability to biosimulation of oral absorption and bioavailability. These methods are all applied in modern molecular biopharmaceutical science, in industrial preformulation and preclinical pharmaceutical development, as well as suggested in various regulatory guidelines.