Cryptolepine, isolated from sida acuta, sensitizes human gastric adenocarcinoma cells to TRAIL-induced apoptosis

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Date
2010
Author
Ahmed, Firoj
Toume, Kazufumi
Ohtsuki, Takashi
Rahman, Mahmudur
Sadhu, Samir Kumar
Ishibashi, Masami
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Abstract
Bioassay guided separation of sida acuta whole plants led to the isolation of an alkaloid, cryptolepine (1), along with two kaempferol glycosides (2–3). Compound 1 showed strong activity in overcoming TRAIL-resistance in human gastric adenocarcinoma (AGS) cells at 1.25, 2.5 and 5 μm. Combined treatment of 1 and TRAIL sensitized AGS cells to TRAIL-induced apoptosis at the aforementioned concentrations.
URI
http://hdl.handle.net/123456789/258
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