Cryptolepine, isolated from sida acuta, sensitizes human gastric adenocarcinoma cells to TRAIL-induced apoptosis

dc.contributor.author	Ahmed, Firoj
dc.contributor.author	Toume, Kazufumi
dc.contributor.author	Ohtsuki, Takashi
dc.contributor.author	Rahman, Mahmudur
dc.contributor.author	Sadhu, Samir Kumar
dc.contributor.author	Ishibashi, Masami
dc.date.accessioned	2014-08-19T23:20:56Z
dc.date.available	2014-08-19T23:20:56Z
dc.date.issued	2010
dc.identifier.citation	Wiley Online Library, 2010	en_US
dc.identifier.uri	http://hdl.handle.net/123456789/258
dc.description.abstract	Bioassay guided separation of sida acuta whole plants led to the isolation of an alkaloid, cryptolepine (1), along with two kaempferol glycosides (2–3). Compound 1 showed strong activity in overcoming TRAIL-resistance in human gastric adenocarcinoma (AGS) cells at 1.25, 2.5 and 5 μm. Combined treatment of 1 and TRAIL sensitized AGS cells to TRAIL-induced apoptosis at the aforementioned concentrations.	en_US
dc.language.iso	en	en_US
dc.publisher	Wiley Online Library	en_US
dc.subject	Sida acuta	en_US
dc.subject	Malvaceae	en_US
dc.subject	Cryptolepine	en_US
dc.subject	TRAIL-induced apoptosis	en_US
dc.subject	AGS cell lines	en_US
dc.title	Cryptolepine, isolated from sida acuta, sensitizes human gastric adenocarcinoma cells to TRAIL-induced apoptosis	en_US
dc.type	Article	en_US