Evaluation of phytochemical and pharmacological properties of mikania cordata (asteraceae) leaves

Abstract

The ethanol extract of the dried leaves of mikania cordata (family-asteraceae) was investigated for its possible bioactive chemical groups and antinociceptive, cytotoxic and antibacterial activities in animal models. The extract produced significant writhing inhibition in acetic acid-induced writhing in mice at the oral dose of 125 and 250 mg/kg body weight (p<0.001) comparable to the standard drug diclofenac sodium at the dose of 25 mg/kg of body weight. The crude extract produced the moderate cytotoxic activity against brine shrimp artemia salina (LC50=90 and LC90=166 μg/ml). The extract showed antibacterial activity against some types of microorganisms upon which the extract was employed. The obtained results provide a support for the use of this plant in traditional medicine and its further investigation.