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dc.contributor.authorKhatun, Amina
dc.contributor.authorRahman, Mahmudur
dc.contributor.authorKabir, Sumaiya
dc.contributor.authorAkter, Md Nahid
dc.contributor.authorChowdhury, Sadia Afreen
dc.date.accessioned2014-08-30T22:50:05Z
dc.date.available2014-08-30T22:50:05Z
dc.date.issued2013
dc.identifier.citationKhatun, Amina; Rahman, Mahmudur; Kabir, Sumaiya; Akter, Md. Nahid and Chowdhury , Sadia Afrin (2013). Phythochemical and pharmacological properties of methanolic extract of ardisia humilis vahl(myrsinaceae), International Journal of Research in Ayurveda & Pharmacy,4(1).en_US
dc.identifier.urihttp://hdl.handle.net/123456789/269
dc.description.abstractArdisia humilisVahl. (Family-Myrsinaceae) has been traditionally used by the folklore medicinal practitioners of Bangladesh to treat cancer, heart diseases and liver poisoning where cytotoxic, thrombolytic and antioxidant medications are implicated. Besides, some other species of Ardisia were reported to have incriminated properties and chemical constituents. In this study, the crude methanolic extract of the A.humilis was evaluated for its possible cytotoxic, thrombolytic and antioxidant activities in different methods to justify some of its folklore use. Cytotoxic property of the extract was determined against brine shrimp nauplii. The thrombolytic activity was evaluated using the standards treptokinase.The antioxidant activity was measured using free radical scavenging activity with 2-2-diphenyl,1- picrylhydrazyl (DPPH) method. The extract showed significant cytotoxic effect in brine shrimp lethality bioassay where it showed the value of LC 50 and LC90 2.26 μg/ml and 7.13μg/ml after 24 hours respectively. The standard cytotoxic drug vincristine sulphate showed LC50 and LC90 of 0.81μg/ml and 6.33 μg/ml after 24 hour respectively. The study gave a significant indication of the use of the plant extract as a potential source for cytotoxic compounds. The extract showed moderate thrombolytic activity of 33.33% clot lysis where the standard streptokinase showed that of 84%. In DPPH free radical scavenging test, IC 50 value for the methanolic crude extract was found fairly significant (4.305 μg/ml) while compared to the IC50 value of the reference standards ascorbic acid (2.8 μg/ml). The obtained results tend to suggest the probable cytotoxic, thrombolytic and antioxidant activities of the methanolic extract of A. humilis justify its use in folkloric remedies and those activities of other species of Ardisia.en_US
dc.language.isoenen_US
dc.publisherInternational Journal of Research in Ayurveda & Pharmacyen_US
dc.subjectArdisia humilisen_US
dc.subjectCytotoxicen_US
dc.subjectAntioxidanten_US
dc.subjectDPPH free - radical scavengingen_US
dc.subjectThrombolyticen_US
dc.subjectStreptokinaseen_US
dc.titlePhytochemical and pharmacological properties of methanolic extract of ardisia humilis vahl (myrsinaceae)en_US
dc.typeArticleen_US


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