Investigation of analgesic and antioxidant activity of ethanolic extract of streblus asper lour. (Moraceae) leaf and bark

Abstract

The ethanol extract of the leaf and bark of streblus asper Lour. (Moraceae) was investigated for its possible analgesic effects in animal models and its antioxidant activities. It exhibited statistically significant writhing inhibition in acetic acid induced writhing inhibition in mice. The crude extract of leaf of 500 mg/kg & 250 mg/kg body weight produced 65.46% & 27.79% inhibition of writhing. On the other hand bark of 500mg/kg & 250mg/kg body weight produced 58.70 % & 20.26% inhibition of writhing respectively; while the standard drug diclofenac inhibition was found to 64.94 % at a dose of 25 mg/kg body weight. The antioxidant property of ethanolic extract of leaf & bark of streblus asper lour. was assessed by DPPH (1, 1-diphenyl-2-picryl hydrazyl) free radical scavenging activity. In DPPH scavenging assay the IC50 value of leaf & bark was found to be 1 µg/ml & 10 µg/ml which were comparable to the standard ascorbic acid.