Biopharmaceutics and clinical pharmacokinetics

Abstract

Biopharmaceutics concerns the relationship between the physical and chemical properties of a drug in a dosage form and the pharmacologic. toxicologic, or clinical response observed after its administration. The study of biopharmaceulics has been extended beyond that of a descriptive discipline by the development of pharmacokinetics which concerns the study and characterization of the time course of drug absorption, distribution, metabolism, and excretion, as well as the relationship of these processes to the intensity and time course of therapeutic and adverse effects of drugs. Pharmacokinetics involves the application of mathematics and biochemistry in a physiologic and pharmacologic context.